Viewing things the way the channel does: Karl Magleby

A conversation with Karl Magleby on short-term synaptic plasticity, discovering BK, and viewing things the way a channel does.

Download PDF transcript

Key words: synaptic plasticity, facilitation, augmentation, potentiation, BK, calcium-activated K channel

A well-channeled journey from heart to brain: Dick Tsien

A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments

Download PDF transcript

Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

Why we don’t twitch when we smoke: Henry Lester

A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording.

Download PDF transcript

Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs

Calcium signaling in the heart: Don Bers

A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes.

Download PDF transcript

Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase

Did Alan Hodgkin dream of calcium sparks? Eduardo Ríos

A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay.

Download PDF transcript

Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin

Getting from “This can’t be right” to “Of course”: Paul Greengard

A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research.

Download PDF transcript

Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3

Fleeing complexity: Chris Miller

A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics.

Download PDF Transcript

Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers